Elevated Serum Chemokine Identified in Patients with Sciatica

by / Monday, 21 September 2015 /

The chemokine MCP-1 may be elevated in patients with sciatica, according to the results of a study.

Participants were 18 or older with lower back pain and sciatica. Every patient underwent a standard clinical examination lumbar spine MRI and blood serum was collected for analysis. Disc prolapse with the presence or absence of nerve root compression was confirmed with MRI.

Sera from a group of 53 patients with radiculopathy confirmed by MRI investigation was compared to 63 participants without radiculopathy recruited from the Haywood Community Hospital in Staffordshire, U.K. The sera were analyzed through duplicate assays for 17 key chemokines and cytokines, including tumor necrosis factor-alpha (TNF-a), interleukin- (IL-) 1, matrix metalloproteinase- 1 (MMP-1), MMP-3, MMP-8 and aggregan and monocyte chemottractant protein-1 (M-1, CCL-2) with a multiplex detection system and median levels were compared.

The 53 patients with MRI-defined radiculopathy had higher levels of MCP-1 (301.4 pg/mL) compared to the 63 patients without radiculopathy (255.7 pg/mL). Thirty patients with severe leg pain and MRI-detected changes had higher levels of MCP-1 (315.9 pg/mL) compared to 85 patients who did not present severe leg pain or changes on MRI (256.7 pg/mL).